Lab Focus/Specialty: Understanding the unique role of beta chemokine CCL2 in extrinsically modulating host ESCRT factors to facilitate HIV-1 budding and replication. Beginning stages to pursue the receptor for CCL2, CCR2 as a potential target for anti-viral drug development. Our recent publication in eLIFE (David Ajasin et al. 2019) has provided novel mechanistic insights into how CCL2 may be involved in several neurological diseases.
Lab Focus/Specialty: Development of near-infrared fluorescent proteins, fluorescent biosensors, and optogenetic tools. Our laboratory is the protein engineering laboratory, with a focus on neuroscience. Laboratory develops fluorescent protein-based tools for detection of neuronal activity, sensing of neuromodulators and neurotransmitters, and enzymatic activation.
Lab Focus/Specialty: Weaponizing the immune system by developing new immunotherapeutics for infectious diseases and cancer including CAR-T cells and novel biologics that enable antigen-specific T cell activation, expansion and differentiation and testing them on novel humanized mouse models. In addition we are using these novel biologics to identify which genes are activated by different costimulatory signals to determine what individual and combined costimulatory signals generate the most potent effector T cells. We are also using novel transgenic mouse models to determine the mechanisms underlying neuroinflammation and cognitive decline associated with HIV infection and/or substance abuse. Website for more specific information: http://www.einstein.yu.edu/departments/microbiology-immunology/
Lab Focus/Specialty: Brain swelling in the experimental model of cerebral malaria (ECM). We are seeking a productive scientist experienced in animal model of infection to lead the program which will define mechanisms of brain swelling through analysis of gene knock out of parasite virulence proteins, metabolomics, histopathology and neuroimaging. Adjunctive therapies will be tested in vivo to improve survival in ECM. Website for more specific information:http://www.einstein.yu.edu/faculty/11598/johanna-daily/
Lab Focus/Specialty: Role of metabolism and bioenergetics in Mycobacterium tuberculosis host adaptation and antibiotic tolerance. We identify vulnerable pathways, translate our findings into drug discovery efforts and determine drug mechanism of action. We use a combination of genetic, metabolomic, transcriptomic and biochemical approaches to understand what makes this pathogen a global threat.
Lab Focus/Specialty: Investigates the epigenetics of embryonic stem cells (ESCs), development and cancer. We utilize ESCs/iPSCs and mice as model systems, and integrate genetic, cellular, molecular and bioinformatics approaches to study how DNA and chromatin modifying enzymes reshape the epigenome and regulate stem cell identity and plasticity in development and disease
Lab Focus/Specialty: Identifying specific roles for glycans in the regulation of Notch signaling during T and B cell development. Mice with targeted mutations in glycan genes and co-culture assays of T cell development have been developed to reveal roles in the differentiation of bone marrow HSC. Identifying independent and synergistic functions for different O-glycans is our goal.
Department Name: Ophthalmology and Visual Sciences
Lab Focus/Specialty: Inherited retinal degeneration is the leading cause of incurable vision loss in industrialized countries. To save and restore vision will have a great impact on the quality of life. Our research aims to elucidate the mechanisms of retinal differentiation and inherited degeneration using engineered mice and human pluripotent stem cells, contributing to regenerative medicine of the retina.
Lab Focus/Specialty: Engineer treatments for disorders of visuospatial learning and memory. To achieve this aim, we perform studies to better our understanding of visuospatial learning and memory functions. We utilize advanced physiological techniques to examine the circuitry of brain structures that are critical for these functions.
Department Name: Anatomy and Structural Biology(Two positions available)
Lab Focus/Specialty: The cell biology of nuclear RNA-protein complexes (RNPs) and how they are impacted by inherited disease. (A) or Studies on a nuclear organelle in epithelial cells of the lining of the uterus (endometrium) as a marker for the readiness of embryo implantation in human reproduction. (B)
Lab Focus/Specialty: Application and development of bioinformatics and genomics methods for mining high throughput functional genomics data (e.g, RNA-seq, scRNA-seq, ChIP-seq and ATAC-seq) to study neural and heart development, psychiatric disorders, and congenital heart defects. The research projects will be focused on constructing gene regulation networks and pathways from integrated analysis of deep sequencing data that are closely related to human and mouse tissue and organ development.
Department Name: Systems and Computational Biology
Lab Focus/Specialty: The research of Wu lab is at the cutting edge of understanding the molecular mechanisms that regulate the intercellular communications and intracellular signaling networks. They develop a large variety of computational and modeling tools and apply them to study different biological problems, including host viral interactions, cancer immunotherapy and spatial organization in neural systems.
Department Name: Genetics (Two positions available)
Lab Focus/Specialty: (A)Cell competition mechanisms-Cell competition is a process by which abnormal cells are eliminated during animal development and is thought to be important in aging and in cancer. Our group has used genetic approaches in fruit flies to identify molecular components of cell competition.A position is available for the molecular characterization of the cell competition pathway and its roles in development and disease using multidisciplinary molecular and genetic approaches. (B) Neural cell fate determination-Proneural bHLH transcription factors are master regulators of neural cell fate determination and differentiation and important components of neuronal reprogramming strategies. We are using genetic screens in Drosophila to identify novel regulators of proneural bHLH proteins. A position is available to characterize the molecular mechanisms using developmental genetic studies, whole-genome sequencing approaches, and protein biochemistry.
Lab Focus/Specialty: Cell competition: a process by which abnormal cells are eliminated during animal development, may be implicated in the prevention and early development of cancer. A project is available to understand the roles of cell competition in the elimination of unfit cells in mammalian tissues. We have prepared a unique series of transgenic mice that will be used to study cell competition during mouse embryonic development under physiological conditions or disease models.
Lab Focus/Specialty: Modeling human brain development and function in a cell culture dish to understand the molecular and cellular basis of disorders such as Parkinsons and Alzheimers disease. We employ an interdisciplinary approach, integrating population genetics and genome-scale epigenetic data combined with human pluripotent stem cell (hPSC) and gene editing technologies, allowing us to investigate how the complex interaction of genetic, epigenetic, and environmental factors contribute to the progression of neurological disorders.
Lab Focus/Specialty: Evaluate novel approaches to telomerase inhibition for children with cancer. Apply your cellular and molecular biology skills, learn bioinformatics, and see real-time results translate into the next clinical research study for relapsed neuroblastoma. We value teamwork, integrity, ambition, enthusiasm, and intellectual curiosity.
Lab Focus/Specialty: Spectroscopy-guided crystallography, enzymology, and inhibitor design. Need assistance with elucidating structure and function relationships of two immunotherapeutic drug targets, human indoleamine 2,3-dioxygenase and tryptophan dioxygenase, and developing inhibitors targeting the enzymes as therapeutic strategies for cancer treatment.
Lab Focus/Specialty: Neural circuits for social behavior at the anatomical, molecular, and functional levels. Our research takes advantage of 1)anatomical studies using viral and dye labeling; 2) molecular profiling using in situ hybridization and sequencing; 3) in vivo imaging using genetically encoded calcium sensors; 4) manipulation of social behavior using optogenetics and chemogenetics.
Lab Focus/Specialty: Uses genetic, molecular, and pharmacologic approaches to identify and validate actionable targets downstream of RB1, studies that could have a broad impact on the treatment of SCLC and other advanced tumors with mutant RB1. Small cell lung cancer (SCLC) is an aggressive tumor for which there are no effective therapies. A defining feature of SCLC is the near uniform bi-allelic inactivation of the RB1 tumor suppressor gene.
Lab Focus/Specialty: Role of stem cell pathways in breast cancer pathogenesis. The research focus of this position will be on stem cell plasticity and epigenetic regulation of mammary stem cells and cancer stem cells. The project will use a wide range of genomics/epigenomics methods, CRISPR genome editing, organoid culture, and in vivo mouse models. Website for more specific information:http://www.einstein.yu.edu/faculty/13006/wenjun-guo/
Lab Focus/Specialty: To understand the regulation of plasma cell differentiation, migration, survival and function in the bone marrow. We are using two-photon intravital imaging in combination with modern cellular and immunological tools to visualize and better understand the physiology of these cells under normal and pathological conditions including multiple myeloma and autoimmunity Website for more specific information:https://sites.google.com/site/fooksmanlab/home/
Lab Focus/Specialty: Enveloped alphaviruses and flaviviruses as highly developed and medically important systems to study virus entry and biogenesis at the molecular level. Potential projects will use multidisciplinary approaches to characterize virus assembly, budding and cell-to-cell transmission. Website for more specific information:https://sites.google.com/site/kielianlab/
Lab Focus/Specialty: The Integrated Imaging Program (IIP) is a joint effort between the Magnetic Resonance Research Center and the Biphotonic Imaging Center to develop ground breaking methods for detecting metastatic breast disease noninvasively. Using microscopic photon imaging to define targets, we then develop MRI methods targeting these targets in vivo in cancer patients. A postdoctoral position developing MRI methods and software for detecting these targets is available within the IIP. Website for more specific information:http://www.einstein.yu.edu/faculty/7459/craig-branch/
Department Name: Department of Medicine/Microbiology and Immunology
Lab Focus/Specialty: Two major translational research areas in the field of tuberculosis (TB) biomarker discovery and correlates of protection. Her group studies human host responses at various states of M. tuberculosis (Mtb) infection with the following overarching goals: i) to inform the development of simple point-of-care tests for TB; and ii) to identify and study potentially protective human antibodies (polyclonal and monoclonal) to inform immunotherapy and TB vaccine development strategies.
Lab Focus/Specialty: The research focus of our translational cancer research laboratory is on investigating novel oncogenic pathways, drug resistance mechanisms, immune biomarkers and new treatment strategies in lung cancer.
Department Name: Bronx-Einstein Training in Teaching and Research (BETTR) program
Lab Focus/Specialty: Focus on increased recruitment of diverse students. This NIH-sponsored enhanced postdoctoral experience, one of 22 nation-wide, consists of 75% effort for research training here at Einstein and 25% effort in mentored teaching activities over a 4-year period. Teaching training occurs at Lehman College and Hostos College, both Hispanic-serving and part of CUNY located in the Bronx. Nearly 70% of our alumni hold faculty positions!
Lab Focus/Specialty: Mycobacterium tuberculosis-host interaction. We are investigating the roles of B cells and antibodies in shaping the immune response to M. tuberculosis, with a focus on the germinal center reaction and IgM. We are also testing the hypothesis that M. tuberculosis exploits the immunosuppressive indoleamine 2,3-dioxygenase pathway of the host to persist.
Lab Focus/Specialty: Important roles of bone neuro-mechanosignaling and inflammation in diabetic osteopenia with the ultimate goal of identifying novel druggable targets to prevent and to treat bone loss in people with diabetes.
Department Name: Radiation Oncology (Two positions available)
Lab Focus/Specialty: Development of regenerative therapies to mitigate acute radiation injury
A)The focus of this project is to develop stem cell-based approaches to stimulate regeneration and induce recovery with an emphasis on intestinal regeneration. We are using in vivo (mouse) and in vitro (organoids) models to study the injury and recovery mechanism. These studies will utilize flow cytometry, confocal imaging, lineage tracing, qRT-PCR, western blot and ELISA to measure organ dysfunction in response to radiation.
B)This project is focused on studying the underlying mechanisms of endothelial dysfunction in the context of radiation exposure. We are using pharmacological and genetic approaches to define the role of vascular niche in radiation injury and recovery. These studies will explore various approaches such as flow cytometry, confocal imaging, lineage tracing, qRT-PCR, western blot, ELISA, metabolomics, SCPECT CT, and MRI to measure organ dysfunction in response to radiation.
Founded in 1955, the Albert Einstein College of Medicine (Einstein) is one of the nation’s premier institutions for medical education, basic research and clinical investigation. A full-time faculty of some 2,000 conducts research, teaches, and delivers health care in every major biomedical specialty. The college has some 730 medical students, 193 Ph.D. students, 106 MD/Ph.D. students and 275 postdoctoral fellows.Einstein’s major strength, in addition to training physicians and scientists, is its science. During fiscal year 2015, the faculty’s consistently high level of scientific achievement resulted in the awarding of more than $150 million in peer-reviewed grants from the National Institutes of Health (NIH).Einstein is part of Montefiore Medicine Academic Health System, an integrated academic delivery system comprising seven campuses, including 8 hospitals, a multi-county ambulatory network, a new state-of-the art “hospital without beds”, a skilled nursing facility, school of nursing, home health agency, and the state’s first freestanding emergency department. As the University Hospital for the Albert Einstein College of Medicine, Montefiore is a premier academic health system, e...mploying Einstein’s clinical faculty and training Einstein’s medical students, over 1,300 residents, 420 allied health students, and 1,600 nursing students annually.The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Einstein seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.